Cajun Chicken Alfredo Fettuccine

Featured in: Everyday Family Meals

This dish features tender chicken breasts seasoned with Cajun spices, cooked to golden perfection, and combined with fettuccine pasta coated in a rich, creamy Velveeta cheese sauce. The sauce blends butter, garlic, cream, Velveeta, and Parmesan for a smooth texture with a hint of heat from cayenne pepper. Garnished with fresh parsley and extra Parmesan, it's a comforting Southern-inspired meal ready in 40 minutes.

Updated on Sun, 23 Nov 2025 11:14:00 GMT
Golden Cajun Chicken Alfredo Fettuccine pasta glistens, showcasing tender chicken in creamy Velveeta sauce. Save to Pinterest
Golden Cajun Chicken Alfredo Fettuccine pasta glistens, showcasing tender chicken in creamy Velveeta sauce. | recipesbies.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

I love making this dish for family dinners because it combines comfort food with a touch of spice that everyone enjoys.

Ingredients

  • Chicken: 2 large boneless, skinless chicken breasts, 1 ½ tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter, 2 cloves garlic minced, 1 cup (240 ml) heavy cream, 8 oz (225 g) Velveeta cheese cubed, ½ cup (50 g) grated Parmesan cheese, ½ teaspoon black pepper, ¼ teaspoon cayenne pepper (optional for extra heat), Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped, Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks, pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet, heat olive oil over medium-high heat. Add chicken and cook 56 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic; sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
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| recipesbies.com

Sharing this dish at family meals always brings smiles and warm memories.

Required Tools

Large pot, Large skillet, Knife and cutting board, Tongs or pasta fork, Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter), Contains wheat (fettuccine), Contains chicken Those with allergies should check ingredient labels for hidden allergens

Nutritional Information

Calories 670 Total Fat 32 g Carbohydrates 57 g Protein 41 g per serving

Rich Velveeta sauce coats the Cajun Chicken Alfredo Fettuccine, topped with fresh parsley and Parmesan. Save to Pinterest
Rich Velveeta sauce coats the Cajun Chicken Alfredo Fettuccine, topped with fresh parsley and Parmesan. | recipesbies.com

This Cajun Chicken Alfredo is a perfect balance of creamy and spicy that can easily become a new family favorite.

Answers to Recipe Questions

How do you ensure the chicken stays tender?

Pat the chicken dry and cook it over medium-high heat until golden and fully cooked, then let it rest before slicing to preserve juiciness.

Can I adjust the spice level in the dish?

Yes, modify the amount of Cajun seasoning and cayenne pepper to suit your preferred heat level.

What pasta works best with this sauce?

Fettuccine is ideal as its wide strands hold the creamy Velveeta sauce well, but other flat noodles can also be used.

How to thin the cheese sauce if it gets too thick?

Add reserved pasta water gradually while stirring until the sauce reaches the desired consistency.

Are there good side dishes to serve with this meal?

A crisp green salad and chilled Chardonnay complement the creamy, spicy flavors nicely.

Cajun Chicken Alfredo Fettuccine

A creamy, spicy dish with Cajun chicken, Velveeta sauce, and fettuccine pasta, perfect for a comforting meal.

Prep duration
15 mins
Time to cook
25 mins
Overall time
40 mins
Published by Sophie Turner


Skill Level Easy

Cuisine Type American (Cajun-inspired)

Serves 4 Serving size

Dietary Details None specified

What you need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon ground black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

How to Make It

Step 01

Cook Fettuccine: Bring a large pot of salted water to a boil. Cook fettuccine according to package instructions until al dente. Drain, reserving ½ cup pasta water, and set aside.

Step 02

Season Chicken: Pat chicken breasts dry and rub both sides evenly with Cajun seasoning.

Step 03

Sear Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden and internal temperature reaches 165°F (74°C). Remove from skillet, let rest for 5 minutes, then slice thinly.

Step 04

Prepare Sauce Base: Reduce heat to medium in the same skillet. Add butter and minced garlic, sautéing for 1 minute until fragrant.

Step 05

Create Creamy Sauce: Pour in heavy cream and bring to a gentle simmer. Add Velveeta cheese cubes and stir frequently until fully melted and smooth.

Step 06

Season Sauce: Incorporate grated Parmesan, black pepper, cayenne pepper if desired, and salt to taste. Adjust sauce thickness by slowly adding reserved pasta water if necessary.

Step 07

Combine Pasta and Sauce: Add cooked fettuccine to the sauce and toss thoroughly to coat.

Step 08

Plate and Garnish: Divide pasta between plates, top with sliced Cajun chicken, garnish with fresh parsley and extra Parmesan cheese as preferred.

Equipment You'll Need

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy Details

Review all ingredients for allergens, and reach out to a healthcare pro if unsure.
  • Contains milk/dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine)
  • Contains poultry

Nutrition info (by portion)

Nutrition info is for guidance. Please consult a medical expert if you need advice.
  • Total Calories: 670
  • Fat content: 32 g
  • Carbohydrate: 57 g
  • Protein content: 41 g